Compared to the fifth generation, the "C6" gets an overhaul of the suspension geometry, all new bodywork with exposed headlamps (for the first time since 1962), a larger passenger compartment, a larger 6.0L and a much higher level of refinement.

For the 2008 model, the Corvette receives a new engine, the LS3. With displacement increased to 6.2 liters, power is increased to 430 hp and 424 lb·ft of torque.

The automatic transmission is set up for quicker shifts giving the C6 Automatic a 0-60 mph time of 4.3 seconds faster than any other production automatic Corvette. The steering has also been tightened up for much improved feel.